History · 2
What disease from the Old World had the most devastating effect on indigenous American populations after 1492?
Answer
Smallpox
Smallpox killed millions of indigenous people who lacked immunity, causing an 80-95% population collapse in some regions.
💡 Did you know?
The demographic catastrophe from disease may have been more influential than conquest in shaping colonial Americas history.
Other options people guess
- Measles
- Typhus
- Bubonic plague
Topics
- Americas
- Disease
Know your history trivia?
Play a free History quiz and see how many you get right — no signup needed to start.
More History facts
History
On what date was the Panama Canal officially completed and handed over to the Panama Canal Zone government?
The Panama Canal locks were one of the greatest engineering works ever undertaken at the time, with massive concrete structures featuring walls 45-55 feet thick at the base.
History
Which country was the first to declare independence from European colonial rule in the Americas?
Haiti's independence in 1804 made it the first Caribbean nation to gain independence and the first successful slave revolution in world history.
History
Who led the Haitian Revolution to its successful conclusion and became Haiti's first independent ruler?
Dessalines became Haiti's first emperor under the 1805 constitution and permanently abolished slavery in the new nation.
History
The Rosetta Stone was discovered during which military campaign in 1799?
The stone bore three scripts (hieroglyphic, Demotic, and Greek), allowing Jean-François Champollion to decipher Egyptian hieroglyphics in 1822.
History
Who was the French military leader who dominated European warfare from 1803-1815?
Napoleon's Grande Armée defeated larger coalitions in battles like Austerlitz, but was ultimately defeated at Waterloo in 1815.
History
What was the Battle of the Three Emperors, one of the most significant Napoleonic battles, also known as?
The Battle of Austerlitz was so decisive that it dissolved the Holy Roman Empire and made Napoleon master of continental Europe.